A sprained MCL could keep Mike Iupati from playing in Week 12.

The San Francisco 49ers could be without left guard Mike Iupati when the team faces the Washington Redskins on Monday Night Football.

Losing Iupati is a major blow to a team coming off back-to-back losses. They have a relatively easy two-game streak against the St. Louis Rams and Washington Redskins before a vital meeting with the Seattle Seahawks. The organization will hope Iupati is at full strength for the Week 14 game.

Browner suffered the injury in a Week 10 game against the Atlanta Falcons. The Seahawks announced he would be inactive against the Minnesota Vikings, but didn’t have any further injury updates until he underwent an MRI.

The injury will hurt a secondary entering a four-game stretch featuring the Saints, 49ers, Giants and Cardinals. Each team has big play potential using several wide receivers capable of catching deep passes. Few teams are better prepared to handle an injury at cornerback than Seattle. The Seahawks will transition to Walter Thurmond, who has played very well in a rotational role after starting two games early this season.

The Texans’ fall-off from fourth in Passing Defense DVOA in 2017 to 25th in 2017 has been the single biggest factor in their demise, even moreso than Schaub getting the pick six named after him. The fourth key insight that those red numbers should get across. Johnathan Joseph has struggled somewhat from a Relative Coverage standpoint, but his Corner Rating (another composite that factors in quarterback rating allowed, Yards Per Attempt allowed and PFF’s ‘eyeball rating’ of coverage) puts him in a better light. He’s given up a ton of yardage, but since he’s so frequently asked to cover the opponent’s No. 1 wideout, he deserves to get graded on a curve. Fellow corner Kareem Jackson has also held up well, continuing a strong career that got off to such a shaky start in 2010.